Menopause relief doesn’t need to be complicated.
HealthiCare’s personalized Bi-Est cream combines two forms of bioidentical estrogen — estriol and estradiol — in one simple topical treatment, prescribed for you by a licensed medical provider and delivered to your door.
Billed monthly · Everything included


Hormonal changes during perimenopause and menopause can affect much more than your period.

Bi-Est combines two forms of bioidentical estrogen into one topical prescription. Bioidentical hormones have the same chemical structure as hormones produced naturally by the human body.
A naturally occurring form of estrogen produced by the body.
The body’s primary and most potent estrogen during reproductive years.
A topical prescription personalized by your provider to help supplement declining estrogen.
No pills or patches.
Your provider determines whether treatment is appropriate and selects your prescription.
No pharmacy trips.
HealthiCare is there throughout your treatment.
For women with a uterus receiving systemic estrogen, progesterone may also be needed to help protect the uterine lining. If the prescribing physician determines progesterone is appropriate for you, progesterone will be added into your personalized Bi-Est cream, giving you estriol, estradiol, and progesterone in one simple topical treatment.
4 simple steps — menopause care without the runaround.
Complete a short online medical intake about your symptoms, health and treatment history.
A licensed provider reviews your information and determines which treatment approach may be appropriate for you.
If prescribed, your medication is prepared and shipped from a licensed US pharmacy directly to your door.
Your provider is available for dose adjustments, check-ins and questions throughout treatment.

Better sleep, steadier moods, fewer flashes — so the day is yours again, not your symptoms’.

*If prescribed. Treatment eligibility and prescription are determined by a licensed medical provider.
Bi-Est isn’t the only menopause treatment available through HealthiCare. We also offer FDA-approved hormone therapies, so you and your provider can choose an approach based on your symptoms, medical history and individual needs.
A convenient transdermal estrogen treatment available in multiple prescription strengths.
Topical estradiol applied directly to the skin.
Oral micronized progesterone that may be prescribed alongside systemic estrogen when clinically appropriate.

Your treatment starts with your symptoms, medical history and individual needs.
Access care online without unnecessary appointments or pharmacy visits.
Every prescription requires review and approval by a licensed medical provider.
Your medication ships directly to your home.
Straightforward treatment pricing without another monthly membership.
Have questions during treatment? HealthiCare is here to help.
Bi-Est is a compounded topical cream that combines two bioidentical estrogens, estriol (E3) and estradiol (E2), into one prescription applied to the skin.
Hormone therapy is commonly used to help address symptoms such as hot flashes, night sweats, sleep disruption, mood changes and vaginal dryness.
No. Bi-Est is a compounded medication and is not FDA-approved. Compounded medications are not reviewed by the FDA for safety or effectiveness. HealthiCare also offers FDA-approved hormone therapies.
Yes. In addition to Bi-Est, we offer FDA-approved options including estradiol patches, estradiol gel and oral micronized progesterone, when clinically appropriate.
For women with a uterus receiving systemic estrogen, a progestogen is generally required to protect the uterine lining. Your provider will determine whether progesterone is appropriate for you.
Often, yes. Share your current treatment during your intake and your provider will review your history to determine the most appropriate approach for you.
This page is for informational purposes only and is not medical advice. Bi-Est is a compounded medication and is not FDA-approved; compounded medications are not reviewed by the FDA for safety or effectiveness. Treatment eligibility and any prescription are determined by a licensed medical provider. Hormone therapy is not appropriate for everyone.